Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research. Product Information Product Name Sulanemadlin Molecular Weight 1930.25 Formula C95H140N20O23 CAS Number 1451199-98-6 Appearance Solid Color White to off-white Sequence Ac-Leu-Thr-Phe-R8-Glu-Tyr-Trp-Ala-Gln-Leu-S5-Ala-Ala-Ala-Ala-Ala-{dAla}-NH2…
Product Name LQEQ-19 (mouse, rat) Biological activity LQEQ-19 (mouse, rat) is a VGF derived peptide that exerts neuroprotective effects. LQEQ-19 (mouse, rat) activates the PI3K/Akt and MEK/ERK signaling pathways by promoting phosphorylation of Akt and ERK1/2. LQEQ-19 (mouse, rat) is commonly used in the study of neurological conditions. Formula Formula C106H165N29O34 CAS Number 322644-72-4 Sequence…
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake. Product Information…
Survodutide (BI 456906) sodium is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide sodium, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide sodium has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food…
SVS-1 peptide is an anticancer peptide. SVS-1 peptide selectively recognizes cancer cells through electrostatic interactions, disrupts cell membrane structure, and leads to cell death. Unlike antimicrobial peptides, the efficacy of SVS-1 peptide occurs before complete neutralization of membrane charge. Product Details Product Name SVS-1 peptide Biological activity SVS-1 peptide is an anticancer peptide. SVS-1 peptide…
SVS-1 peptide acetate is an anticancer peptide. SVS-1 peptide acetate selectively recognizes cancer cells through electrostatic interactions, disrupts cell membrane structure, and leads to cell death. Unlike antimicrobial peptides, the efficacy of SVS-1 peptide acetate occurs before complete neutralization of membrane charge. Product Details Product Name SVS-1 peptide acetate Biological activity SVS-1 peptide acetate is…
SYNV-cyclo(CGGYF) is a C5 autoinducing peptide of the human commensal Staphylococcus hominis. SYNV-cyclo(CGGYF) inhibits the activity of Staphylococcus aureus. SYNV-cyclo(CGGYF) has potential for studying S. aureus-mediated epithelial damage and inflammation. Product Details Product Name SYNV-cyclo(CGGYF) Biological activity SYNV-cyclo(CGGYF) is a Staphylococcus hominis (S. hominis) C5 autoinducing peptide. SYNV-cyclo(CGGYF) inhibits S. aureus activity. SYNV-cyclo(CGGYF) has the…
SYNV-cyclo(CGGYF) TFA is a C5 autoinducing peptide of the human commensal Staphylococcus hominis. SYNV-cyclo(CGGYF) TFA inhibits the activity of Staphylococcus aureus. SYNV-cyclo(CGGYF) TFA has potential for studying S. aureus-mediated epithelial damage and inflammation. Product Details Product Name SYNV-cyclo(CGGYF) TFA Biological activity SYNV-cyclo(CGGYF) TFA is a Staphylococcus hominis (S. hominis) C5 autoinducing peptide. SYNV-cyclo(CGGYF) TFA inhibits…
Product Name Neuronostatin-13 (human) Biological activity Neuronostatin-13 human is a 13-amino acid peptide hormone encoded by the somatostatin gene and plays an important role in the regulation of hormonal and cardiac function. Molecular Weight 1415.68 Formula Formula C64H110N20O16 CAS Number 1096485-24-3 Appearance Solid Color White to off-white Sequence Shortening Sequence Shortening LRQFLQKSLAAAA-NH2 Storage Sealed storage,…
Tachyplesin I is a ??-hairpin antimicrobial peptide containing 17 amino acid residues. Tachyplesin I exhibits cytotoxic properties against various human tumor cell lines, primarily by impairing the integrity of the outer cell membrane. Product Details Product Name Tachyplesin I Biological activity Tachyplesin I is a ??-hairpin antimicrobial peptide that contains 17 amino acid residues. Tachyplesin…
Tachyplesin I TFA is a ??-hairpin antimicrobial peptide containing 17 amino acid residues. Tachyplesin I TFA exhibits cytotoxic properties against various human tumor cell lines, primarily by impairing the integrity of the outer cell membrane. Product Details Product Name Tachyplesin I TFA Biological activity Tachyplesin I TFA is a ??-hairpin antimicrobial peptide that contains 17…
Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects against Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds bacterial membrane lipopolysaccharide through positive charges, disrupts membrane integrity, and causes leakage of cellular contents. Tachyplesin II binds to the DNA minor groove, inhibits microbial replication, and also inhibits HIV-1…
Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. Tachyplesin-3 has inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and enveloped viruses. Tachyplesin-3 binds bacterial membrane lipopolysaccharide through positive charges, disrupts membrane integrity, and causes leakage of cellular contents. Tachyplesin-3 interferes with bacterial adhesion and aggregation, prevents biofilm formation, and has a synergistic effect when combined with…
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM. Product Information Product Name TAK-448 Molecular Weight 1225.36 Formula C58H80N16O14 CAS Number 1234319-68-6 Appearance Solid Color White to off-white Sequence Shortening Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2 Sequence Shortening Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2 Storage Sealed storage, away from moisture Powder -80??C 2…
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 ??M). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7…
Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 ??M). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric…
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