Peptide Linker
Peptide linker&spacer create the new strategy in custom peptide design.
Peptide linker is also known as peptide spacer, it is flexible or stretch molecule to link 2 different molecules, such as a fluorophore to one or two peptides. According to different field of peptide design and application, we can construct different linkers & spacers in peptides with different molecules. Generally, the common linker&spacer in peptides including:
- Peptide and biotin
- Peptide and carrier proteins
- Peptide and fluorescent dyes
- Peptide and tags
Different length of linkers can bind to differnt site of peptides via the amide bond.
The common hydrophobic spacer is aminohexanoic acid (Ahx), A common hydrophilic spacer is polyethylene glycol (PEG), PEGylation is applied widely for improvement of peptide stability and bio-availability in vivo.
Advantage of Linker&Spacer
- Improve possibility in peptide design
- Further study in peptide structure and function
- Critical mechanism information of peptide synthesis
- Stabilize model enzymes for new peptide drugs
Common Peptide linkers
Beta-alanine
GABA
AEA
Ava
Ahx
PEG2 Spacer
PEG3 Spacer
PEG4 Spacer
Ttds
Furthermore, peptide linkers are enzymatically cleavable linkers. Due to the superior plasma stability and release mechanism, peptide linkers gain significant attention in antibody-drug conjugates (ADCs) developments. Qyaobio provides high-quality service for design and synthesis of peptide linker. Our peptide linkers have expected stability and better drug release controlling.
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