Survodutide sodium
Description
Survodutide (BI 456906) sodium is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide sodium, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide sodium has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake.
Product Information
| Product Name | Survodutide sodium |
| Molecular Weight | 4231.63 (free base) |
| Formula | C192H289N47O61??xNa |
| Appearance | Solid |
| Sequence | His-{1-Aminocyclobutanecarboxylic acid}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Arg-Ala-Ala-Lys-Asp-Phe-Ile-{Lys(Gly-Gly-Ser-Gly-Ser-Gly-γGlu-C18 diacid)}-Trp-Leu-Glu-Ser-Ala-NH2 |
| Sequence Shortening | H-{1-Aminocyclobutanecarboxylic acid}-QGTFTSDYSKYLDERAAKDFI-{Lys(GGSGSG-γGlu-C18 diacid)}-WLESA-NH2 |
| Storage | Sealed storage, away from moisture Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture) |
