Talfirastide
Description
Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 ??M). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
Product Information
| Product Name | Talfirastide |
| Molecular Weight | 899.00 |
| Formula | C41H62N12O11 |
| CAS Number | 51833-78-4 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Asp-Arg-Val-Tyr-Ile-His-Pro |
| Sequence Shortening | DRVYIHP |
| Storage | Sealed storage, away from moisture Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture) |
