3-WP
Description
3-WP is a linear icosapeptide with C-terminal amidation modification. 3-WP acts on lipoteichoic acid (LTA) and disrupts cell wall permeability, induces intracellular reactive oxygen species (ROS) accumulation in a dose-dependent manner, and inhibits respiratory chain dehydrogenase activity and intracellular ATP synthesis, thereby interfering with bacterial energy metabolism and exerting antibacterial effects. Combined use of 3-WP with Melittin (HY-P0233) produces synergistic antibacterial activity against Gram-positive bacteria, reducing the required dose of Melittin and thereby improving Melittin’s cell selectivity. 3-WP can serve as a peptide adjuvant for Melittin in food storage scenarios. 3-WP can be used in research on foodborne diseases caused by methicillin-resistant Staphylococcus aureus.
Product Details
| Product Name | 3-WP |
| Biological activity | 3-WP is a linear 20-peptide with a C-terminal amidation modification. 3-WP acts on lipoteichoic acid (LTA) and disrupts cell wall permeability, induces intracellular reactive oxygen species (ROS) accumulation in a dose-dependent manner, and simultaneously inhibits respiratory chain dehydrogenase activity and intracellular ATP synthesis, thereby interfering with bacterial energy metabolism and exerting Bacterial antibacterial effects. The combination of 3-WP and Melittin (HY-P0233) exerts synergistic antibacterial effects against Gram-positive bacteria, reduces the required dosage of Melittin, and thus improves the cell selectivity of Melittin. 3-WP can serve as a peptide adjuvant for Melittin in food storage scenarios. 3-WP can be used in the research of foodborne diseases caused by methicillin-resistant Staphylococcus aureus. |
| Formula | C135H183N41O20 |
| Sequence | Trp-Pro-Arg-Pro-Trp-Pro-Arg-Pro-Trp-Pro-Arg-Pro-Trp-Pro-Arg-Pro-Trp-Pro-Arg-Pro-NH2 |
| Sequence Shortening | WPRPWPRPWPRPWPRPWPRP-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
