Protegrin-1
Description
Protegrin-1 is an orally active antimicrobial peptide. Protegrin-1 activates ERK, COX2, and NF??B, and inhibits apoptosis and NO production. Protegrin-1 has antibacterial activity against Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with MBC values ranging from 10 to 20 ??M. Protegrin-1 has antiviral activity against dengue virus NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in research on inflammatory diseases and infections.
Product Details
| Product Name | Protegrin-1 |
| Biological activity | Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NF??B, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 ??M. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections. |
| Molecular Weight | 2155.61 |
| Formula | C88H147N37O19S4 |
| CAS Number | 168831-77-4 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Arg-Gly-Gly-Arg-Leu-Cys-Tyr-Cys-Arg-Arg-Arg-Phe-Cys-Val-Cys-Val-Gly-Arg-NH2 (Disulfide bridge:Cys6-Cys15;Cys8-Cys13) |
| Sequence Shortening | RGGRLCYCRRRFCVCVGR-NH2 (Disulfide bridge:Cys6-Cys15;Cys8-Cys13) |
| Storage | Sealed storage, away from moisture |
