Periplanetasin-4
Description
Periplanetasin-4 is an antimicrobial peptide that can be extracted from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and downstream activation of p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium levels in Candida albicans ATCC 90028 cells, decreases DPH fluorescence intensity, and causes vacuolar dysfunction. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse intestine. Periplanetasin-4 can be used in research on colitis.
Product Details
| Product Name | Periplanetasin-4 |
| Biological activity | Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis. |
| Formula | C70H110N20O15S |
| CAS Number | 2206807-06-7 |
| Sequence | Leu-Arg-His-Lys-Val-Tyr-Gly-Tyr-Cys-Val-Leu-Gly-Pro-NH2 |
| Sequence Shortening | LRHKVYGYCVLGP-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
