Pap12-6-10
Description
Pap12-6-10 is an MD-2 ligand that binds the MD-2 hydrophobic pocket to inhibit TLR4/MD-2 complex dimerization and downstream inflammatory signaling; it also binds LPS to permeabilize bacterial cell membranes and induce oxidative stress leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and has antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows a low tendency to induce resistance and low preclinical cytotoxicity, and can prevent organ damage in a mouse model of sepsis. Pap12-6-10 can be used in research on Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections.
Product Details
| Product Name | Pap12-6-10 |
| Biological activity | Pap12-6-10 is an MD-2 ligand that binds to the hydrophobic pocket of MD-2 to inhibit the dimerization of the TLR4/MD-2 complex and downstream inflammatory signal transduction. Pap12-6-10 also binds to LPS to permeabilize bacterial cell membranes and induce oxidative stress, leading to bacterial death. Pap12-6-10 regulates LPS-induced inflammatory responses through the TLR4 signaling pathway and exhibits antibacterial activity against multidrug-resistant Gram-negative bacteria. Pap12-6-10 shows low tendency to induce drug resistance and low preclinical cytotoxicity, and it prevents organ damage in a mouse model of sepsis. Pap12-6-10 can be used for research related to Gram-negative sepsis and carbapenem-resistant Acinetobacter baumannii infections. |
| Molecular Weight | 1631.06 |
| Formula | C82H131N23O12 |
| Sequence | {d-Arg}-{d-Trp}-{d-Lys}-{d-Ala}-{d-Phe}-{d-Lys}-{d-Lys}-{d-Leu}-{d-Leu}-{d-Lys}-{d-Lys}-{d-Trp}-NH2 |
| Sequence Shortening | rwkafkkllkkw-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
