Brevicidine
Description
Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to polysaccharides (LPS) on the bacterial cell membrane and forming pores. Brevicidine causes dissipation of the proton motive force, outer membrane disruption, inhibition of ATP biosynthesis, and accumulation of reactive oxygen species in bacterial cells. As a sensitizer, Brevicidine exhibits synergistic activity when combined with various conventional antibiotics.
Product Details
| Product Name | Brevicidine |
| Biological activity | Brevicidine is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens. Brevicidine disrupts bacterial morphology by binding to lipopolysaccharide (LPS) on the bacterial cell membrane to form pores. Brevicidine causes dissipation of intracellular proton motive force, outer membrane damage, inhibition of ATP biosynthesis and reactive oxygen species accumulation in bacterial cells. As a sensitizer, Brevicidine exerts synergistic activity when combined with a variety of conventional antibiotics. |
| Molecular Weight | 1519.74 |
| Formula | C74H106N18O17 |
| CAS Number | 2676889-05-5 |
| Sequence | 4-Methylhexanoyl-{d-Asn}-{d-Tyr}-{d-Trp}-{d-Orn}-{Orn}-Gly-{d-Orn}-Trp-Thr-Ile-Gly-Ser (Lactone: Thr9-Ser12) |
| Sequence Shortening | 4-Methylhexanoyl-{d-Asn}-{d-Tyr}-{d-Trp}-{d-Orn}-{Orn}-G-{d-Orn}-WTIGS (Lactone: Thr9-Ser12) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
