WLBU2
Description
WLBU2 is an engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental susceptibility issues of natural antimicrobial peptides (AMPs). WLBU2 exhibits rapid bactericidal effects, with MIC values ?? 10 ??M against a variety of Gram-positive and Gram-negative bacteria (including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus, Klebsiella pneumoniae, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, etc.). WLBU2 prevents the biofilm growth of Pseudomonas aeruginosa, retains activity in mucus-rich, low-pH, and high-salt environments, and has no adverse effects on human respiratory epithelial cells. WLBU2 can be used in research on cystic fibrosis (CF) and P. aeruginosa infection.
Product Details
| Product Name | WLBU2 |
| Biological activity | WLBU2 is a engineered cationic antimicrobial peptide (eCAP) that overcomes the environmental sensitivity of natural antimicrobial peptides (AMPs). WLBU2 exhibits rapid bactericidal effect, with the MIC values of ?? 10 ??M against both Gram-negative and Gram-positive bacteria including MRSA, vancomycin-resistant enterococci, K. pneumoniae, E.aerogenes, E. cloacae, Escherichia coli, et, al. WLBU2 prevents P. aeruginosa biofilm growth and retains its activity in an environment rich in mucus, low pH and high salt concentrations without negative effects on human airway epithelial cells. WLBU2 can be used for the studies of cystic fibrosis (CF) and Pseudomonas aeruginosa infections. |
| CAS Number | 847061-43-2 |
| Sequence | Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg |
| Sequence Shortening | RRWVRRVRRWVRRVVRVVRRWVRR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
