Polymyxin B nonapeptide
Description
Polymyxin B nonapeptide is a cationic cyclic peptide. Polymyxin B nonapeptide is a derivative produced by enzymatic cleavage of Polymyxin B. Compared with Polymyxin B, Polymyxin B nonapeptide has lower toxicity and lacks bactericidal activity, but retains the ability to disrupt the outer membrane of Gram-negative bacteria.
Product Details
| Product Name | Polymyxin B nonapeptide |
| Biological activity | Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. |
| Formula | C43H74N14O11 |
| CAS Number | 86408-36-8 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9) |
| Sequence Shortening | T-{Dab}-{Dab}-{Dab}-d-FL-{Dab}-{Dab}-T (Lactam: Dab3-Thr9) |
| Storage | Sealed storage, away from moisture and light |
