W(Dab)L
Description
W(Dab)L is a cationic membrane-lytic antimicrobial peptide with protease stability, salt tolerance, and no induction of drug resistance. W(Dab)L is effective against planktonic MRSA, MRSA biofilms, and Pseudomonas aeruginosa, with relatively low cytotoxicity against mammalian cells. As a bactericidal agent, W(Dab)L selectively interacts with negatively charged bacterial membranes, causing membrane permeabilization, deformation, disintegration, leakage of intracellular contents, and ultimately cell lysis. W(Dab)L maintains chemical integrity and antibacterial activity after exposure to proteases and human serum. W(Dab)L can be used in research on methicillin-resistant Staphylococcus aureus infections.
Product Details
| Product Name | W(Dab)L |
| Biological activity | W(Dab)L is a cationic membrane-disrupting antimicrobial peptide with protease stability, salt tolerance, and no induction of drug resistance. W(Dab)L is effective against planktonic MRSA, MRSA biofilms, and Pseudomonas aeruginosa, and exhibits low cytotoxicity to mammalian cells. As a bactericide, W(Dab)L selectively interacts with negatively charged bacterial membranes, triggering membrane permeabilization, deformation, disintegration, intracellular substance leakage, and ultimately leading to cell lysis. W(Dab)L maintains its chemical integrity and antimicrobial activity upon exposure to proteases and human serum. W(Dab)L can be used in studies of methicillin-resistant Staphylococcus aureus infections. |
| Sequence | Trp-{(Rac)-Dab}-Trp-Leu-{(Rac)-Dab}-{(Rac)-Dab}-Leu-Leu-NH2 |
| Sequence Shortening | W-{(Rac)-Dab}-WL-{(Rac)-Dab}-{(Rac)-Dab}-LL-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
