Tritrpticin
Description
Tritrpticin is a porcine antimicrobial peptide with membrane disruption and hemolytic properties. Tritrpticin disrupts the membranes of bacteria, fungi, and Jurkat T-cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against Trichomonas vaginalis, reduces plasma endotoxin and inflammatory cytokine levels, limits bacterial growth in blood and visceral tissues, reduces the lethality of septic shock in rats, and enhances the efficacy of ertapenem. Tritrpticin has selective cytotoxicity against Jurkat T-cell leukemia cells while having low toxicity against normal peripheral blood mononuclear cells and erythrocytes, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied in research on bacterial infections, fungal infections, trichomoniasis, septic shock, and leukemia.
Product Details
| Product Name | Tritrpticin |
| Biological activity | Tritrpticin is a porcine-derived antimicrobial peptide with properties such as membrane disruption and hemolysis. Tritrpticin disrupts the cell membranes of bacteria, fungi and Jurkat T cell leukemia cells and induces their death. Tritrpticin also enhances the efficacy of Metronidazole (HY-B0318) against *Trichomonas vaginalis*, reduces plasma endotoxin and inflammatory cytokine levels, restricts bacterial growth in blood and visceral tissues, decreases the mortality rate of septic shock in rats and enhances the therapeutic effect of ertapenem. Tritrpticin exhibits selective cytotoxicity against Jurkat T cell leukemia cells, while showing low toxicity to normal peripheral blood mononuclear cells and red blood cells, and can serve as a template for antimicrobial peptide design. Tritrpticin can be applied to research related to bacterial infections, fungal infections, trichomoniasis, septic shock and leukemia. |
| Formula | C96H132N28O14 |
| CAS Number | 179264-81-4 |
| Sequence | Val-Arg-Arg-Phe-Pro-Trp-Trp-Trp-Pro-Phe-Leu-Arg-Arg |
| Sequence Shortening | VRRFPWWWPFLRR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
