Thanatin
Description
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-induced ??-hairpin AMP containing a single disulfide bond. Thanatin exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria as well as various fungi, with MIC values of 0.3-40 ??M, 0.6-40 ??M, and 0.6-20 ??M, respectively. Thanatin has the property of competitively displacing divalent cations on the bacterial outer membrane (OM), leading to OM disruption.
Product Details
| Product Name | Thanatin |
| Biological activity | Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing ??-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 ??M, 0.6-40 ??M and 0.6-20 ??M, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption. |
| Formula | C103H177N35O27S3 |
| CAS Number | 214542-43-5 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18) |
| Sequence Shortening | GSKKPVPIIYCNRRTGKCQRM (Disulfide bridge:Cys11-Cys18) |
| Storage | Sealed storage, away from moisture |
