SAAP 148
Description
SAAP 148 is a synthetic antimicrobial peptide that interacts with and damages the lipid bilayer of the bacterial cytoplasmic membrane, leading to altered membrane permeability and bacterial death. SAAP 148 kills drug-resistant, multidrug-resistant, and persister strains, inhibits biofilm formation, eradicates preformed biofilms, and blocks bacterial colonization of implant surfaces. SAAP 148 retains activity after modification or immobilization, exhibits different cytotoxicity in different human cell models, and its efficacy decreases in protein-rich environments. SAAP 148 can be used in infection-related research.
Product Details
| Product Name | SAAP 148 |
| Biological activity | SAAP 148 is a synthetic antimicrobial peptide (bacteria) that interacts with and disrupts the lipid bilayer of bacterial cytoplasmic membranes, thereby inducing changes in membrane permeability and bacterial death. SAAP 148 kills drug-resistant, multidrug-resistant and persister bacterial strains, inhibits biofilm formation, eliminates established biofilms, and blocks bacterial colonization on implant surfaces. SAAP 148 retains its activity after modification or immobilization, exhibits variable cytotoxicity in different human cell models, and shows reduced efficacy in protein-rich environments. SAAP 148 can be used in infection-related research. |
| Formula | C157H261N49O27 |
| Sequence | Ac-Leu-Lys-Arg-Val-Trp-Lys-Arg-Val-Phe-Lys-Leu-Leu-Lys-Arg-Tyr-Trp-Arg-Gln-Leu-Lys-Lys-Pro-Val-Arg-NH2 |
| Sequence Shortening | Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
