PR-39
Description
PR-39 is a proline- and arginine-rich natural antimicrobial peptide and a non-competitive, reversible, allosteric proteasome inhibitor. PR-39 reversibly binds to the ??7 subunit of the proteasome and blocks the degradation of the NF-??B inhibitor I??B?? through the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis in mice, inhibits inflammatory responses, and significantly reduces myocardial infarction size.
Product Details
| Product Name | PR-39 |
| Biological activity | PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the ??7 subunit of the proteasome and blocks degradation of NF-??B inhibitor I??B?? by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice. |
| Formula | C229H346N70O40 |
| CAS Number | 139637-11-9 |
| Sequence Shortening | RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
