HVF18-a3-d
Description
HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-?? and IL-6, reduces ROS production, and inhibits the TLR4 signaling pathway and LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antibacterial activity against a variety of bacteria by disrupting the bacterial outer and inner membranes. HVF18-a3-d protects mice from lethal septic shock caused by carbapenem-resistant Acinetobacter baumannii. HVF18-a3-d has anti-inflammatory and antioxidant effects.
Product Details
| Product Name | HVF18-a3-d |
| Biological activity | HVF18-a3-d is an antimicrobial peptide. HVF18-a3-d reduces NO production. HVF18-a3-d inhibits the production of TNF-?? and IL-6, reduces ROS production, and suppresses the TLR4 signaling pathway, as well as LPS-induced phosphorylation of ERK, JNK, and p38 MAPK. HVF18-a3-d exhibits antimicrobial activity against a variety of bacteria by disrupting their outer and inner membranes. HVF18-a3-d protects mice from fatal septic shock induced by Acinetobacter baumannii resistant to Carbapenem. HVF18-a3-d shows anti-inflammatory and antioxidant effects. |
| Sequence | d-{Gly-Val-Phe-Arg-Leu-Lys-Lys-Trp-Leu-Lys-Lys-Val-Leu-Lys-Lys-Trp-Gly-Lys}-NH2 |
| Sequence Shortening | d-{GVFRLKKWLKKVLKKWGK}-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
