Hs02
Description
Hs02, a cationic amphipathic antimicrobial peptide derived from a human protein, is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against a variety of human pathogens, with MIC values as low as 2 ??M against Staphylococcus aureus and Escherichia coli and MBC values of 2-4 ??M. Hs02 kills bacteria mainly by disrupting the integrity of the bacterial cell membrane, with relatively low selectivity for eukaryotic cell membranes. Hs02 induces cells to release IL-12 but not IL-6, suggesting a certain pro-inflammatory or immune-activating potential. Hs02 can be used in antibacterial and immunomodulatory research.
Product Details
| Product Name | Hs02 |
| Biological activity | Hs02 is a cationic amphiphilic antibacterial peptide derived from human proteins, and it is the membrane-active module of the core chimeric peptide Chim2. Hs02 exhibits broad-spectrum and potent antibacterial activity against various human pathogenic bacteria with the MIC for Staphylococcus aureus and Escherichia coli of as low as 2 ??M, and the MBC is 2-4 ??M. Hs02 primarily kills bacteria by disrupting the integrity of the bacterial cell membrane, and it has a relatively low selectivity for eukaryotic cell membranes. Hs02 induces the release of IL-12 but does not induce the release of IL-6, indicating its potential for pro-inflammatory or immune activation. Hs02 can be used in antibacterial and immunomodulatory research. |
| Sequence | Lys-Trp-Ala-Val-Arg-Ile-Ile-Arg-Lys-Phe-Ile-Lys-Gly-Phe-Ile-Ser-NH2 |
| Sequence Shortening | KWAVRIIRKFIKGFIS-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
