Histatin-3 TFA
Description
Histatin-3 TFA is a peptide composed of 32 amino acids with potent antibacterial properties. Histatin-3 TFA serves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at the C-terminal side of a single Arg25 residue (HRGYR reduces SN). Histatin-3 TFA is a moderately effective, reversible, and competitive inhibitor of furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an inhibition constant Ki of approximately 1.98 ??M.
Product Details
| Product Name | Histatin-3 TFA |
| Biological activity | Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 ??M. |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-Arg-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn |
| Sequence Shortening | DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN |
| Storage | Sealed storage, away from moisture and light |
