TRV-120027
Description
TRV120027, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages β-arrestins while blocking G-protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R-β-arrestin-1-TRPC3-PLCγ at the plasma membrane. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 has the potential for the acute decompensated heart failure (ADHF) treatment.
Product Information
| Product Name | TRV-120027 |
| Molecular Weight | 926.07 |
| Formula | C43H67N13O10 |
| CAS Number | 1234510-46-3 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Shortening {Sar}-RVYIHP-{d-Ala} |
| Sequence Shortening | {Sar}-RVYIHP-{d-Ala} |
| Storage | Sealed storage, away from moisture and light, under nitrogen Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
