TRV-120027 TFA
Description
TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling. TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R?Cβ-arrestin-1?CTRPC3?CPLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II?Cmediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment.
Product Information
| Product Name | TRV-120027 TFA |
| Molecular Weight | 1040.10 |
| Formula | C45H68F3N13O12 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | {Sar}-Arg-Val-Tyr-Ile-His-Pro-{d-Ala} |
| Sequence Shortening | {Sar}-RVYIHP-{d-Ala} |
| Storage | Sealed storage, away from moisture and light Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture and light) |
