Rusalatide acetate
Description
Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.
Product Information
| Product Name | Rusalatide acetate |
| Molecular Weight | 2371.50 |
| Formula | C99H151N29O37S |
| CAS Number | 875455-82-6 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Shortening AGYKPDEGKRGDACEGDSGGPFV-NH2 |
| Sequence Shortening | AGYKPDEGKRGDACEGDSGGPFV-NH2 |
| Storage | Sealed storage, away from moisture and light Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture and light) Solvent & Solubility ϸ??ʵ?飺? H2O Peptide Solubility and Storage Guidelines: 1.??Calculate the length of the peptide. 2.??Calculate the overall charge of the entire peptide according to the following table: ? Contents Assign value Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1 Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1 Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0 3.??Recommended solution: Overall charge of peptide Details Negative (<0) 1.??Try to dissolve the peptide in water first. 2.??If water fails, add NH4OH (<50 ??L). 3.??If the peptide still does not dissolve, add DMSO (50-100 ??L) to solubilize peptide. Positive (>0) 1.??Try to dissolve the peptide in water first. 2.??If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3.??If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. Zero (=0) 1.??Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2.??For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. ???? & ??Ʒ???? Data Sheet (518 KB) SDS (252 KB) ??Ʒʹ??ָ?? (1538 KB) ?ο????? . Kantara C, et al. Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. Lab Invest. 2015 Nov;95(11):1222-33. ? |
