Retrocyclin-1
Description
Retrocyclin-1 is a cationic cyclic ??-defensin peptide. Retrocyclin-1 binds with high affinity to the HIV-1 gp41 ectodomain in a glycan-independent manner, with a Kd of 67.6 nM, and selectively targets the gp41 C-terminal heptad repeat region. Retrocyclin-1 has broad-spectrum antiviral activity against HIV-1, herpes simplex virus, and influenza A virus in vitro, and can inhibit HIV-1 infection in cell models and cervicovaginal tissue models. Retrocyclin-1 also possesses innate immune defense activity. Retrocyclin-1 can be used in research on human immunodeficiency virus type 1 and HIV-1 infection.
Product Details
| Product Name | Retrocyclin-1 |
| Biological activity | Retrocyclin-1 is a cationic cyclic ??-defensin peptide. Retrocyclin-1 binds to the extracellular domain of HIV-1 gp41 with high affinity in a glycan-independent manner, with a Kd of 67.6 nM, and selectively targets the C-terminal heptad repeat region of gp41. Retrocyclin-1 exhibits broad-spectrum antiviral activity against HIV-1, herpes simplex virus and influenza A virus in vitro, and inhibits HIV-1 infection in cell models and cervicovaginal tissue models. Retrocyclin-1 also possesses innate immune defense activity. Retrocyclin-1 can be used in research related to human immunodeficiency virus type 1 and HIV-1 infection. |
| CAS Number | 724760-19-4 |
| Sequence | Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) (Disulfide bridge:Cys2-Cys11;Cys4-Cys9;Cys13-Cys18) |
| Sequence Shortening | RCICGRGICRCICGRGIC (Disulfide bridge:Cys2-Cys11;Cys4-Cys9;Cys13-Cys18) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
