PRO20
Description
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC50 value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents.
Product Information
| Product Name | PRO20 |
| Molecular Weight | 2341.82 |
| Formula | C105H181N31O27S |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Leu-Pro-Thr-Arg-Thr-Ala-Thr-Phe-Glu-Arg-Ile-Pro-Leu-Lys-Lys-Met-Pro-Ser-Val-Arg |
| Sequence Shortening | LPTRTATFERIPLKKMPSVR |
| Storage | Stored under nitrogen, away from moisture Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (stored under nitrogen, away from moisture) |
