Polymyxin B nonapeptide TFA
Description
Polymyxin B nonapeptide TFA is a cationic cyclic peptide. Polymyxin B nonapeptide TFA is a derivative produced by enzymatic cleavage of Polymyxin B. Compared with Polymyxin B, Polymyxin B nonapeptide TFA has lower toxicity and lacks bactericidal activity, but retains the ability to disrupt the outer membrane of Gram-negative bacteria.
Product Details
| Product Name | Polymyxin B nonapeptide TFA |
| Biological activity | Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. |
| Formula | C43H74N14O11.5C2HF3O2 |
| CAS Number | 2220175-42-6 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9) |
| Sequence Shortening | T-{Dab}-{Dab}-{Dab}-{d-Phe}-L-{Dab}-{Dab}-T (Lactam: Dab3-Thr9) |
| Storage | Sealed storage, away from moisture |
