Plecanatide
Description
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.
Product Information
| Product Name | Plecanatide |
| Molecular Weight | 1681.89 |
| Formula | C65H104N18O26S4 |
| CAS Number | 467426-54-6 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bridge: Cys4-Cys12; Cys7-Cys15) |
| Sequence Shortening | NDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15) |
| Storage | Sealed storage, away from moisture Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture) |
