PCC16 chloride
Description
PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 ??M for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers. (Pink: DHHC3 ligand (HY-169235); Blue: Cereblon ligand (HY-10984); Black: linker (HY-169236)).
Product Information
| Product Name | PCC16 chloride |
| Molecular Weight | 4764.69 |
| Formula | C206H322ClN67O60S |
| Sequence | {Rhodmine B}-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Gly-Ile-Gln-Asp-Thr-Asn-Ser-Lys-Lys-Gln-Ser-Asp-Thr-His-Leu-Glu-Glu-Thr-{Lys(pomalidomide-Suc-PEG2)}-NH2 |
| Sequence Shortening | {Rhodmine B}-YGRKKRRQRRRCGIQDTNSKKQSDTHLEET-{Lys(pomalidomide-Suc-PEG2)}-NH2 |
