Iturin A-2
Description
Iturin A-2 is a cyclic lipopeptide that can be found in B. subtilis and has inhibitory activity against the plant pathogenic fungus P. expansum (MIC of 8 ??g/disc). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells and HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 ??g/mL, respectively. In greenhouse studies, Iturin A-2 at 100 and 300 mg/kg reduced the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg reduced the incidence of southern corn leaf blight. Iturin A-2 (12.5 ??g/mL) also inhibits cytokinesis of isolated fertilized starfish eggs without affecting nuclear division.
Product Details
| Product Name | Iturin A-2 |
| Biological activity | Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 ??g/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC50 values of 66.81, 95.04, and 77.5 ??g/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 ??g/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs. |
| Sequence | Cyclo({d-Asn}-Gln-Pro-{d-Asn}-Ser-{(3R)-3-aminotetradecanoic acid}-Asn-{d-Tyr}) |
| Sequence Shortening | Cyclo({d-Asn}-QP-{d-Asn}-S-{(3R)-3-aminotetradecanoic acid}-N-{d-Tyr}) |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
