FuK
Description
FuK is a WK2 analog antimicrobial peptide modified with fluorinated non-natural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, no hemolytic activity, and high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing bacterial outer membrane permeability, inducing cytoplasmic membrane depolarization, and disrupting membrane potential homeostasis, and is effective against Gram-positive and Gram-negative bacteria including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK acts synergistically with Polymyxin B (HY-149179), Vancomycin (HY-B0671), and Ciprofloxacin (HY-B0356), and also inhibits ciprofloxacin-induced bacterial resistance. FuK is safe in vivo, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds.
Product Details
| Product Name | FuK |
| Biological activity | FuK is a WK2-analog antimicrobial peptide modified with fluorinated unnatural amino acids. FuK has an LD50 of 72.34 mg/kg in mice, shows no hemolytic activity, with high stability against trypsin, chymotrypsin, and saline environments. FuK exerts bactericidal effects by enhancing the permeability of bacterial outer membranes, inducing depolarization of cytoplasmic membranes, and disrupting membrane potential balance against bacterias such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and MRSA. FuK exhibits synergistic antimicrobial activity with polymyxin B (HY-149179), vancomycin (HY-B0671), and ciprofloxacin (HY-B0356), and also inhibits Ciprofloxacin-induced bacterial drug resistance. FuK has in vivo safety, effectively reduces bacterial load and inflammatory cell infiltration in a mouse MRSA model, and promotes collagen fiber formation in skin wounds. |
| Sequence | Gly-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-Ile-NH2 |
| Sequence Shortening | G-{Fup}-{Fup}-{d-Lys}-{d-Lys}-{Fup}-{Fup}-{d-Lys}-{d-Lys}-I-NH2 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
