Fonagepant
Description
Fonagepant (FE 205030) is a calcitonin gene-related peptide (CGRP) receptor antagonist with an IC50 of 0.2 nM. Fonagepant selectively blocks CGRP receptor activity, inhibits CGRP-induced vasodilation, attenuates capsaicin-induced increase in skin blood flow, and blocks CGRP-induced vasodilation in isolated human mesenteric resistance arteries. Fonagepant can be used in studies related to acute migraine attacks.
Product Information
| Product Name | Fonagepant |
| Molecular Weight | 1425.63 |
| Formula | C66H88N16O16S2 |
| CAS Number | 1966181-14-5 |
| Sequence | {d-Val}-{Phe(CONH2)}-Cys-{Orn(1-methylethyl)}-Asp-Val-Gly-Pro-Phe-Cys-{Val(3-pyridinyl)}-NH2 (Disulfide bridge: Cys3-Cys10) |
| Sequence Shortening | {d-Val}-{Phe(CONH2)}-C-{Orn(1-methylethyl)}-DVGPFC-{Val(3-pyridinyl)}-NH2 (Disulfide bridge: Cys3-Cys10) |
