Enicepatide
Description
Enicepatide (CT-388) is a cAMP signal-biased dual GLP-1R and GIPR agonist peptide, with an EC50 value of 0.087 nM for GLP-1R cAMP, and an EC50 value of 2.47 nM for GIPR cAMP. Enicepatide activates the cAMP signaling pathway, while recruiting only minimal amounts of β-arrestin-2 at both targets and reducing receptor internalization levels. Enicepatide improves glycemic control, reduces body weight, suppresses appetite, and ameliorates the pathological conditions of metabolic dysfunction-associated steatohepatitis. Enicepatide can be used in the research of obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis.
Product Information
| Product Name | Enicepatide |
| Molecular Weight | 4825.44 |
| Formula | C226H345FN48O67 |
| CAS Number | 2869147-44-2 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | {3’CN,2’F-Phenylisobutyric-βAla}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{Lys((AEEA)2-γGlu-C20 diacid)}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Sequence Shortening | {3’CN,2’F-Phenylisobutyric-βAla}-EGTFTSDYSI-{Aib}-LDKIAQ-{Lys((AEEA)2-γGlu-C20 diacid)}-AFVQWLIAGGPSSGAPPPS-NH2 |
| Storage | Sealed storage, away from moisture and light, under nitrogen Powder -80??C 2 years -20??C 1 year *In solvent : -80??C, 6 months; -20??C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
