Difelikefalin
Description
Difelikefalin (CR-845; FE-202845) is an orally active peripherally acting kappa opioid receptor agonist. Difelikefalin reduces acute kidney injury, decreases oliguria, maintains urine flow, inhibits cytokine expression, and improves survival in endotoxemia after ischemia/reperfusion. Difelikefalin suppresses pruritus signals and exhibits neuromodulatory antipruritic activity. Difelikefalin can be used in research related to acute kidney injury, chronic kidney disease-associated pruritus, and atopic dermatitis.
Product Information
| Product Name | Difelikefalin |
| Molecular Weight | 679.85 |
| Formula | C36H53N7O6 |
| CAS Number | 1024828-77-0 |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | D(Phe-Phe-Leu-Lys)-{4-aminonipecotic acid} |
| Sequence Shortening | D(FFLK)-{4-aminonipecotic acid} |
