C-VGB3
Description
C-VGB3 is a selective vascular endothelial growth factor receptor 2 (VEGFR2) antagonist, which inhibits VEGFR2-mediated PI3K/AKT/mTOR and PLCγ/ERK1/2 signaling pathways. C-VGB3 binds to the extracellular domain of VEGFR2, blocking ligand-receptor interaction and inducing apoptosis in endothelial and tumor cells through both intrinsic (involving Bcl2 family and caspases) and extrinsic (death receptor-mediated) pathways. C-VGB3 is promising for research of angiogenesis-related cancers, such as breast cancer.
Product Information
| Product Name | C-VGB3 |
| Molecular Weight | 1102.20 |
| Formula | C43H67N13O17S2 |
| Sequence | Glu-Cys-Arg-Pro-Pro-Asp-Asp-Gly-Leu-Cys (Disulfide bridge: Cys2-Cys10) |
| Sequence Shortening | ECRPPDDGLC (Disulfide bridge: Cys2-Cys10) |
