APH-IN-1
Description
APH-IN-1 is an aminoglycoside phosphotransferase (APH) inhibitor with a Kd value of 63 nM against E. coli APH(3??)-Ia. APH-IN-1 binds mainly to the ATP-binding pocket of APH(3??)-Ia in an ATP-competitive manner, and divalent metal ions (Mg2+ and Ca2+) enhance binding affinity. APH-IN-1 can be used in research on aminoglycoside-resistant bacterial infections.
Product Details
| Product Name | APH-IN-1 |
| Biological activity | APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a Kd values of 63 nM against Escherichia coli APH(3??)-Ia. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg2+ and Ca2+). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
