Calcitonin Gene-Related Peptide

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Calcitonin gene-related peptide(CGRP) is a 37-amino acid neuropeotide, it is a member of calcitonin family of peptides, it is consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2, and calcitonin‑receptor‑stimulating peptide.

CGRP has protective mechanisms in the cardiovascular system, it is a highly potent vasodilator.  It is secreted and stored in the nervous system with two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II).

Notice: All peptides are only for research purposes, Not for clinical use.

CGRP Peptides

1.Calcitonin, salmon
  • Name: Calcitonin, salmon
  • Sequence: CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-NH2 (Remark: Disulfide bond)
  • CAS Number: [47931-85-1]
  • Formula: C145H240N44O48S2
  • Characteristics: Cys1 and 7 bridge
  • Reference: DC.R. Hamilton, Am. J. Med., 56, 858 (1974)
2.Calcitonin, human
  • Name: Calcitonin, human
  • Sequence: CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-NH2 (Remark: Disulfide bond)  
  • CAS Number: [21215-62-3]
  • Formula: C151H226N40O45S3
  • Characteristics: Cys1 and 7 bridge
  • Reference: Y. Nakagawa, et al., Peptide Chemistry, 1976, 189 (1977)
3.Calcitonin Gene Related Peptide, humanα-CGRP (human)
  • Name: Calcitonin Gene Related Peptide, human|α-CGRP (human)
  • Sequence: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2  (Remark: Disulfide bond)
  • CAS Number: [90954-53-3]
  • Formula: C163H267N51O49S2
  • Characteristics: Cys2 and 7 bridge
  • Reference: P.Le Greves et al., Eur. J. Pharmacol., 115, 309 (1985)  H.R.Morris et al., Nature, 308, 746 (1984)
4.α-CGRP (8-37) (human)Calcitonin Gene Related Peptide (8-37), human
  • Name: α-CGRP (8-37) (human)|Calcitonin Gene Related Peptide (8-37), human
  • Sequence: VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2
  • CAS Number: [119911-68-1]
  • Formula: C139H230N44O38
  • Characteristics: None
  • Reference: T. Chiba et al., Amer. J. Physiol., 256, E331 (1989)
5.Calcitonin Gene Related Peptide, rat
  • Name: Calcitonin Gene Related Peptide, rat
  • Sequence: SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2  (Remark: Disulfide bond)
  • CAS Number: [96827-03-1]
  • Formula: C162H262N50O52S2
  • Characteristics: Cys2 and 7 bridge
  • Reference: S.G. Amara, V. Jonas, M.G. Rosenfeld, E.S. Ong and R.M. Evans, Nature, 298, 240 (1982) (Original)  M.G. Rosenfeld, J.J. Mermond, S.G. Amara, L.W. Swanson, P.E. Sawchenko, J. Rivier, W.W. Vale and R.M. Evans, Nature, 304, 129 (1983)
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