Amyloid

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Beta Amyloid Peptide is an amyloid plaques peptide in brains of Alzheimer’s disease (AD) patients, it consists of 43 amino acid. The peptides derive from the amyloid-beta precursor protein (APP), APP is cleaved by beta secretase and gamma secretase, then creates Amyloid beta in the cholesterol-dependent process and substrate presentation. Beta Amyloid then aggregates to flexible insoluble oligomers, and causes amyloidosis and neurodegenerative diseases. In addition, these misfold oligomers can induce other β-Amyloid in misfoled forms, leading to the chain reaction of prion infection.

Qyaobio can synthesize a comprehensive array of beta amyloid peptides covering stretches of its amino acid sequence, in order to ease the process of elucidating the potential biological interactions of each specific fragment.

Notice: All peptides are only for research purposes, Not for clinical use.

Amyloid Peptides

1.β-Amyloid (17-40)
  • Name: β-Amyloid (17-40)
  • Sequence: SLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C110H178N26O31S1
  • Characteristics: None
  • Reference: None
2.β-Amyloid A4 Protein Precursor (APP) (96-110), analog
  • Name: β-Amyloid / A4 Protein Precursor (APP) (96-110), analog
  • Sequence: Ac-NWCKRGRKQCKTHPH-NH2 ( Remark: Disulfide bond)
  • CAS Number: None
  • Formula: C81H128N32O19S2
  • Characteristics: Cys&Cys bridge
  • Reference: D.H. Small et al., J. Neurosci., 14, 2117 (1994)
3.β-Amyloid Peptide (1-42), rat
  • Name: β-Amyloid / A4 Protein Precursor (APP) (96-110), analog
  • Sequence: DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C199H307N53O59S1
  • Characteristics: None
  • Reference: E. Paradis et al., J. Neurosci., 16, 7533 (1996)  J. Murrell et al., Science, 254, 97 (1991)  D. Goldgabber et al., Science, 235, 877 (1987)
4.β-Amyloid (1-42), HClbeta-Amyloid (1-42), HCl
  • Name: β-Amyloid (1-42), HCl|beta-Amyloid (1-42), HCl
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Remark: chloride salt)
  • CAS Number: [107761-42-2]
  • Formula: C203H311N55O60S1
  • Characteristics: None
  • Reference: Neurobiology of Aging, 13, No.5 (1992)  K.Takata et al., J. Pharmacol. Sci., 91, 330 (2003)
5.beta-Amyloid (1-42), TFA
  • Name: beta-Amyloid (1-42), TFA
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: [107761-42-2]
  • Formula: C203H311N55O60S1
  • Characteristics: None
  • Reference: A.Jan et al., Nat. Protoc., 5, 1186 (2010)  W.B.Stine et al., Methods Mol. Biol. , 670, 13 (2011)
6.β-Amyloid (40-1)beta-Amyloid (40-1)
  • Name: β-Amyloid (40-1)|beta-Amyloid (40-1)
  • Sequence: VVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD
  • CAS Number: [144409-99-4]
  • Formula: C194H295N53O58S1
  • Characteristics: None
  • Reference: N.W. Kowall et al., Proc. Nat. Acad. Sci. USA, 88, 7247 (1991)
7.β-Amyloid (1-28)beta-Amyloid (1-28)
  • Name: β-Amyloid (1-28)|beta-Amyloid (1-28)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNK
  • CAS Number: [109770-29-8]
  • Formula: C145H209N41O46
  • Characteristics: None
  • Reference: J. Kang et al., Nature, 325, 773 (1987)
8.β- Amyloid Protein Precursor 770 (135 - 155)
  • Name: β- Amyloid Protein Precursor 770 (135 – 155)
  • Sequence: FLHQERMDVCETHLHWHTVAK
  • CAS Number: [315229-44-8]
  • Formula: C116H173N35O31S2
  • Characteristics: None
  • Reference: G.Multhaup et al., Science, 271, 1406 (1996)
9.Fam-beta-Amyloid (1-42)
  • Name: Fam-beta-Amyloid (1-42)
  • Sequence: 5-FAM-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C224H321N55O66S1
  • Characteristics: None
  • Reference: Neurobiology of Aging, 13, No.5 (1992)
10.Tamra-beta-Amyloid (1-42)
  • Name: Tamra-beta-Amyloid (1-42)
  • Sequence: 5-TAMRA-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C228H331N57O64S1
  • Characteristics: None
  • Reference: Neurobiology of Aging, 13, No.5 (1992)
11.Biotinyl- beta-Amyloid (1-42)
  • Name: Biotinyl- beta-Amyloid (1-42)
  • Sequence: Biotin-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C213H325N57O62S2
  • Characteristics: None
  • Reference: None
12.beta-Amyloid (1-40)
  • Name: beta-Amyloid (1-40)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C194H295N53O58S1
  • Characteristics: None
  • Reference: B.A. Yankner et al., Science, 250, 279 (1990)
13.Biotin-beta-Amyloid (1-40)
  • Name: Biotin-beta-Amyloid (1-40)
  • Sequence: Biotin-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C204H309N55N60S2
  • Characteristics: None
  • Reference: B.A. Yankner et al., Science, 250, 279 (1990)
14.Tamra-beta-Amyloid (1-40)
  • Name: Tamra-beta-Amyloid (1-40)
  • Sequence: 5-TAMRA-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C219H315N55O62S1
  • Characteristics: None
  • Reference: B.A. Yankner et al., Science, 250, 279 (1990)
15.beta-Amyloid (17-42)
  • Name: beta-Amyloid (17-42)
  • Sequence: LVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C119H194N28O33S1
  • Characteristics: None
  • Reference: None
16.beta-Amyloid (22-35)
  • Name: beta-Amyloid (22-35)
  • Sequence: EDVGSNKGAIIGLM
  • CAS Number: None
  • Formula: C59H102N16O21S1
  • Characteristics: None
  • Reference: T. Takadera et al., Neurosci. Letters, 161, 41 (1993)
17.beta-Amyloid (1-38)
  • Name: beta-Amyloid (1-38)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGG
  • CAS Number: None
  • Formula: C184H277N51O56S1
  • Characteristics: None
  • Reference: M.P. Mattson, J. Neurosci., 12, 376 (1992)
18.beta-Amyloid / A4 Protein Precursor (APP)
  • Name: beta-Amyloid / A4 Protein Precursor (APP)
  • Sequence: Ac-NWCKRGRKQCKTHPH-NH2 (Remark: Disulfide bond)
  • CAS Number: None
  • Formula: C81H128N32O19S2
  • Characteristics:  (Cys bridge)
  • Reference: D.H. Small et al., J. Neurosci., 14, 2117 (1994)
19. Beta-Sheet Breaker Peptide iAbeta5p
  • Name: Beta-Sheet Breaker Peptide iAbeta5p，[Pro18, Asp21]-ß-Amyloid (17-21), iAb5
  • Sequence: LPFFD
  • CAS Number: [182912-74-9]
  • Formula: C33H43N5O8
  • Characteristics: None
  • Reference: None
20.Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid b
  • Name: Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid b
  • Sequence: RE(Edans)EVNLDAEFK(Dabcyl)R
  • CAS Number: [310427-94-2]
  • Formula: C91H129N25O25S1
  • Characteristics: None
  • Reference: A.K. Ghosh et al., J. Amer. Chem. Soc., 122, 3522 (2000) J. Ermolieff et al., Biochemistry, 39, 12450 (2000)
21.(Asn670,Leu671)-Amyloid b
  • Name: (Asn670,Leu671)-Amyloid b
  • Sequence: SEVNLDAEFR
  • CAS Number: [186142-28-9]
  • Formula: C50H78N14O19
  • Characteristics:  None
  • Reference: F. Grüninger-Leitch, et al., Nat. Biotechnol. 18, 66 (2000);S. Sinha, et al., Nature 402, 537 (1999);R. Vasser, et al., Science 286, 735 (1999);R. Yan, et al., Nature 402, 533 (1999)
22.Amyloid beta-Protein (25-35)
  • Name: Amyloid beta-Protein (25-35)
  • Sequence: GSNKGAIIGLM
  • CAS Number: [131602-53-4]
  • Formula: C45H81N13O14S1
  • Characteristics: None
  • Reference: I.D.Limon et al., Neurosci. Res., 63, 129 (2009);L.Millucci et al., Curr. Protein Pept. Sci., 11, 54 (2010);H.-H.G.Tsai et al., Proteins, 78, 1909 (2010)
23.Non-Abeta Component of Alzheimer's Disease Amyloid
  • Name: Non-Abeta Component of Alzheimer’s Disease Amyloid
  • Sequence: EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV
  • CAS Number: [154040-19-4]
  • Formula: C141H235N39O49
  • Characteristics: None
  • Reference: H.Han et al., Chemistry and Biology, 2, 163 (1995);A.Iwai et al., Biochemistry, 34, 10139 (1995)
24.[Arg3]-Amyloid beta-Protein (1-40)
  • Name: [Arg3]-Amyloid beta-Protein (1-40)
  • Sequence: DARFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C195H300N56O56S
  • Characteristics:  None
  • Reference: None
25.[Arg15, Asp16,25 ,Pro18,21,23 ,Val22 ,Ile24]-Amyloid ß-Protein (15-25)
  • Name: [Arg15, Asp16,25 ,Pro18,21,23 ,Val22 ,Ile24]-Amyloid ß-Protein (15-25)
  • Sequence: RDLPFFPVPID
  • CAS Number: [182912-63-6]
  • Formula: C64H94N14O16
  • Characteristics: None
  • Reference: None
26.[D-Asp1]-Amyloid-beta-Protein (1-42)
  • Name: [D-Asp1]-Amyloid-beta-Protein (1-42)
  • Sequence: dAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA(Remark:d is D-Asp)
  • CAS Number: None
  • Formula: C203H311N55O60S
  • Characteristics: None
  • Reference: None
27.[Gln11]-beta-Amyloid (1-16)
  • Name: [Gln11]-beta-Amyloid (1-16)
  • Sequence: DAEFRHDSGYQVHHQK
  • CAS Number: [133605-53-5]
  • Formula: C84H120N28O27
  • Characteristics:  None
  • Reference: None
28. [Gln11]-beta-Amyloid (1-28)
  • Name: [Gln11]-beta-Amyloid (1-28)
  • Sequence: DAEFRHDSGYQVHHQKLVFFAEDVGSNK
  • CAS Number: [106686-61-7]
  • Formula: C145H210N42O45
  • Characteristics: None
  • Reference: None
29.[Gln11]-beta-Amyloid (1-40)
  • Name: [Gln11]-beta-Amyloid (1-40)
  • Sequence: DAEFRHDSGYQVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C194H296N54O57S
  • Characteristics: None
  • Reference: None
30.[Gln22]-beta-Amyloid (1-40)
  • Name: [Gln22]-beta-Amyloid (1-40)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C194H296N54O57S
  • Characteristics:  None
  • Reference: None
31. [Gln22]-beta-Amyloid (6-40)
  • Name: [Gln22]-beta-Amyloid (6-40)
  • Sequence: HDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C167H258N46O48S
  • Characteristics: None
  • Reference: None
32. [Gln9]-Amyloid beta-Protein (1-40)
  • Name: [Gln9]-Amyloid beta-Protein (1-40)
  • Sequence: DAEFRHDSQYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C197H300N54O59S
  • Characteristics: None
  • Reference: None
33.[Gly22]-beta-Amyloid (1-40)
  • Name: [Gly22]-beta-Amyloid (1-40)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV
  • CAS Number: None
  • Formula: C191H291N53O56S
  • Characteristics:  None
  • Reference: None
34.[Gly22]-Amyloid beta-Protein (1-42)
  • Name: [Gly22]-Amyloid beta-Protein (1-42)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVVIA
  • CAS Number: None
  • Formula: C200H307N55O58S
  • Characteristics: None
  • Reference: None
35.[Gly28,Cys30]-Amyloid ß-Protein (1-30)
  • Name: [Gly28,Cys30]-Amyloid ß-Protein (1-30)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNGGC-NH2
  • CAS Number: None
  • Formula: C146H209N43O47S
  • Characteristics: None
  • Reference: None
36. [Gly30,Cys31]-beta-Amyloid (13-31)
  • Name: [Gly30,Cys31]-beta-Amyloid (13-31)
  • Sequence: HHQKLVFFAEDVGSNKGGC
  • CAS Number: None
  • Formula: C91H137N27O27S
  • Characteristics:  None
  • Reference: None
37.[Ile34]-beta-Amyloid (25-34)
  • Name: [Ile34]-beta-Amyloid (25-34)
  • Sequence: GSNKGAIIGI
  • CAS Number: None
  • Formula: C40H72N12O13
  • Characteristics: None
  • Reference: None
38.[Lys15]-Amyloid beta-Protein (15-21)
  • Name: [Lys15]-Amyloid beta-Protein (15-21)
  • Sequence: KKLVFFA
  • CAS Number: [190775-14-5]
  • Formula: C44H69N9O8
  • Characteristics: None
  • Reference: None
39.[Pyr11]-Amyloid beta-Protein (11-40)
  • Name: [Pyr11]-Amyloid beta-Protein (11-40)
  • Sequence: (Pyr)-VHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  • CAS Number: [192377-94-9]
  • Formula: C143H226N38O39S
  • Characteristics:  None
  • Reference: None
40.[Pyr3]-Amyloid beta-Protein (3-42)
  • Name: [Pyr3]-Amyloid beta-Protein (3-42)
  • Sequence: (Pyr)-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • CAS Number: [183449-57-2]
  • Formula:  C196H299N53O55S
  • Characteristics: None
  • Reference: None
41.[Val35]-beta-Amyloid (1-42)
  • Name: [Val35]-beta-Amyloid (1-42)
  • Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLVVGGVVIA
  • CAS Number: None
  • Formula:  C203H311N55O60
  • Characteristics: None
  • Reference: None
42.beta-Amyloid (1-11)
  • Name: beta-Amyloid (1-11)
  • Sequence: DAEFRHDSGYE
  • CAS Number: [190436-05-6]
  • Formula: C56H76N16O22
  • Characteristics:  None
  • Reference: None
43.beta-Amyloid (1-14) , mouse, rat
  • Name: beta-Amyloid (1-14) , mouse, rat
  • Sequence: DAEFGHDSGFEVRH
  • CAS Number: None
  • Formula: C69H95N21O24
  • Characteristics: None
  • Reference: None
44.beta-Amyloid (1-15)
  • Name: beta-Amyloid (1-15)
  • Sequence: DAEFRHDSGYEVHHQ
  • CAS Number: [183745-81-5]
  • Formula: C78H107N25O27
  • Characteristics: None
  • Reference: None
45.Parallel topology beta-Amyloid modified peptide
  • Name: Parallel topology beta-Amyloid modified peptide
  • Sequence: CHQKLVFFAEDYNGKDEAFFVLKQHW
  • CAS Number: None
  • Formula: C151H211N37O39S
  • Characteristics:  None
  • Reference: None
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