Adrenomedullin

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Adrenomedullin (ADM) is an endogenous vasodilatory peptide that consists of 52 amino acids and has a wide range of diverse effects and functions. ADM and its receptors are widely distributed in various tissues and are highly expressed in blood vessels. It belongs to the calcitonin gene-related peptide (CGRP) superfamily of vasoactive peptide hormones, and plays a pivotal role in various regulatory mechanisms, particularly those of the cardiovascular and lymphatic system.

ADM exerts biological effects by activation of the calcitonin receptor-like receptor (CLR) as a complex with one of three receptor activity-modifying proteins (RAMP), which alter the ligand affinity. It is seen as a positive influence in diseases such as hypertension, myocardial infarction, chronic obstructive pulmonary disease and other cardiovascular diseases, whereas it can be seen as a negative factor in potentiating the ability of cancerous cells to extend their blood supply and thereby enable further cell proliferation.

Notice: All peptides are only for research purposes, Not for clinical use.

Adrenomedullin Peptides

1.Adrenomedullin (1-50), rat
  • Name: Adrenomedullin (1-50), rat
  • Sequence: YRQSMNQGSRSTGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGY-NH2
  • CAS Number: [161383-47-7]
  • Formula: C242H381N77O75S5
  • Characteristics: Cys14&Cys19 bridge
  • Reference: J. Sakata et al., BBRC, 195, 921 (1993)
2.Adrenomedullin (22-52), human
  • Name: Adrenomedullin (22-52), human
  • Sequence: TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
  • CAS Number: [156106-32-0]
  • Formula: C159H252N46O48
  • Characteristics: Cys17 and 28 bridge
  • Reference: None
3.Adrenomedullin (1-52), human
  • Name: Adrenomedullin (1-52), human
  • Sequence: YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
  • CAS Number: [148498-78-6]
  • Formula: C264H406N80O77S3
  • Characteristics: Cys16 and Cys21 bridge
  • Reference: K. Kitamura et al., BBRC, 192, 533 (1993)  C. Nuki et al., BBRC, 196, 245 (1993)
4.Adrenomedullin (13-52), human
  • Name: Adrenomedullin (13-52), human
  • Sequence: SFGCRFGTCTVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
  • CAS Number: [154765-05-6]
  • Formula: C200H308N58O59S2
  • Characteristics: Cys4 and Cys9 bridge
  • Reference: Gumusel, Bulent, et al. American Journal of Physiology-Heart and Circulatory Physiology 274.4 (1998): H1255-H1263.  Chu, Duc Quyen, et al. British journal of pharmacology 130.7 (2000): 1589-1596.
5.Adrenomedullin (1-12), human
  • Name: Adrenomedullin (1-12), human
  • Sequence: SNPAMAPRERKAGCKNFFWKTFTSC
  • CAS Number: [76461-17-1]
  • Formula: None
  • Characteristics: None
  • Reference: None
6.Proadrenomedullin (1-20) (human)|Pro-Adrenomedullin (N-20), human
  • Name: Proadrenomedullin (1-20) (human)
  • Sequence: ARLDVASEFRKKWNKWALSR-NH2
  • CAS Number: [150238-87-2]
  • Formula: C112H178N36O27
  • Characteristics: None
  • Reference: K. Kitamura et al., BBRC, 194, 720 (1993)
7.Adrenomedullin (rat)
  • Name: Adrenomedullin (rat)
  • Sequence: YRQSMNQGSRSTGCRFGTCTMQKLAHQIYQF TDKDKDGMAPRNKISPQGY-NH2
  • CAS Number: [161383-47-7]
  • Formula: None
  • Characteristics: Disulfidebond
  • Reference: None
8.Adrenomedullin (26-52) (human)
  • Name: Adrenomedullin (26-52) (human)
  • Sequence: LAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
  • CAS Number: None
  • Formula: C139H216N40O42
  • Characteristics: None
  • Reference: None
9.Proadrenomedullin (12-20) (human)
  • Name: Proadrenomedullin (12-20) (human)
  • Sequence: KWNKWALSR-NH2
  • CAS Number: None
  • Formula: C56H86N18O11
  • Characteristics: None
  • Reference: None
10.Adrenomedullin 5 (primate)
  • Name: Adrenomedullin 5 (primate)
  • Sequence: HQVPQHRGHVCYLGVCRTHRLAEIIQWIRSASTKEPTGKASREPQNPYSY-NH2
  • CAS Number: None
  • Formula: None
  • Characteristics: Disulfidebond
  • Reference: None
11.Adrenomedullin (16-31) (human, pig)
  • Name: Adrenomedullin (16-31) (human, pig)
  • Sequence: CRFGTCTVQKLAHQIY-NH2
  • CAS Number: None
  • Formula: C82H129N25O21S2
  • Characteristics: Disulfidebond
  • Reference: None
12.Adrenomedullin (1- 52), porcine
  • Name: Adrenomedullin (1- 52), porcine
  • Sequence: YRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFTDKDKDGVAPRSKISPQGY-NH2
  • CAS Number: None
  • Formula: C262H403N79O76S3
  • Characteristics: Disulfidebond
  • Reference: None
13.Adrenomedullin (11-50), rat
  • Name: Adrenomedullin (11-50), rat
  • Sequence: STGCRFGTCTMQKLAHQIYQFTDKDKDGMAPRNKISPQGY-NH2
  • CAS Number: [163648-32-6]
  • Formula: C194H304N58O59S4
  • Characteristics: Cys4-Cys9 bridge
  • Reference: None
14.Prepro-Adrenomedullin (153-185), human
  • Name: Prepro-Adrenomedullin (153-185), human
  • Sequence: SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL
  • CAS Number: None
  • Formula: C143H224N42O43
  • Characteristics: None
  • Reference: None
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