Showing 193–208 of 281 results
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Melanoma-associated antigen 4 (MAGE-A4) is one of the most common cancer testis antigens in humans. It is expressed in various solid cancers such as synovial sarcoma and is an important therapeutic target for cancer vaccination and autologous T cell therapies such as Afamitresgene autoleucel (Afami-cel).Peptide-loaded MHC MACSimers are offered in various peptide-MHC allele combinations covering a broad range of T cell antigens. MHC MACSimer A*0201 MAGE-A4 can be used for immune response monitoring in cancer patients undergoing (autologous) T cell therapy targeting MAGE-A4, i.e.
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The MAGE-A4 Peptide (286-294, KVLEHVVRV) is a peptide corresponding to MAGE-A4 (Melanoma-associated antigen 4), amino acids 286-294. . It also corresponds to MAGE-A8, amino acids 288-296. The MAGE-A4 peptide is widely used to stimulate human MAGE-A4-specific CD8+ T cells or as negative control in the stimulation of human MAGE-A1-specific CD8+ T cells.
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A fusion tag, called MDYKDHDGDYKDHDIDYKDDDDK including an enterokinase-cleavage site, was specifically designed for immunoaffinity chromatography.
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Melittin, a 26-residue bee venom peptide, is known to induce murine antibodies specific for its hydrophilic C-terminus of residues 20 to 26 and T-cell responses specific for its hydrophobic mid-region .This peptide is an anti-inflammatory agent, it inhibits the lyme disease spirochete.
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This peptide is a TRP-tyrosinase-related protein. Its immunization results in effective induction of antitumor immunity. Key Diseases for which peptide SVYDFFVWL is Melanoma, Neoplasms(cancer),Glioma. Drugs related to peptide SVYDFFVWL include mRNA, Liposomes, DNA, Atigens, Epitopes.
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Myelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes and has been implicated as an important autoantigen in multiple sclerosis (MS). This peptide induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
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Myelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes and has been implicated as an important autoantigen in multiple sclerosis (MS). This peptide induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
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Recently Neurogranin (48-76) was identified as a major neurogranin peptide fragment in human brain and it was found that patients with Alzheimer’s Disease have elevated levels of Neurogranin (48-76) in cerebrospinal fluid.
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Neuropeptide Y (NPY) is a vasoconstrictor and a brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Neuropeptide Y (NPY) is implicated in the control of blood pressure, sexual behavior, and food intake. Neuropeptide Y (NPY) inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.
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SLLMWITQC is a linear peptidic epitope (epitope ID 59278) studied as part of Cancer/testis antigen 1 from Homo sapiens (human). This TCR-like antibody specifically targets to HumanNY-ESO-1 antigen that recognizes epitope SLLMWITQC presented on HLA-A*02:01. This product is mainly used to treat Melanoma.
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Orexins are synthesized by posterolateral neurons in hypothalamus. They bind to orexin-1 (OxR1) and orexin 2 (OxR2) receptors. Orexin A can bind to both OxR1 and OxR2 while Orexin B can associate with OxR2 only. Both Orexins are involved in the regulation of arousal and sleep states, energy homeostasis, and autonomic central control.
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G4 peptide (SIIGFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).
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This is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb.
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OVA peptide 323-339 represents a T and B cell epitope of OVA, which is important in the generation and development of immediate hypersensitivity responses in BALB/c mice. Daily aerosolization of OVA 323-339 for 20 minutes over a period of 10 days has been as effective in the stimulation of a serum anti-OVA IgE antibody response as sensitization to native OVA by the same route. After sensitization to native OVA, the majority of the IgE anti-OVA response is directed against OVA peptide 323-339.
