β-Amyloid (1–42) Peptide (Aβ1-42)
High-purity synthetic β-Amyloid 1–42 peptide for Alzheimer’s disease research, aggregation studies, neurotoxicity assays, and protein misfolding research.
Overview
β-Amyloid (1–42), also known as Aβ1-42 or Abeta42, is a 42-amino-acid peptide derived from amyloid precursor protein (APP). It is one of the most studied peptides in Alzheimer’s disease research due to its strong tendency to aggregate into oligomers and fibrils.
Compared with Aβ1-40, Aβ1-42 has a higher hydrophobicity and stronger aggregation propensity, making it a key model for studying amyloid plaque formation.
Applications
Alzheimer’s Disease Research
Used to study amyloid plaque formation and neurodegeneration mechanisms.
Protein Aggregation Studies
Model peptide for fibril formation and misfolding kinetics.
Neurotoxicity Assays
Evaluate cell toxicity in neuronal and brain cell models.
Drug Screening
Used for screening aggregation inhibitors and therapeutic compounds.
Amino Acid Sequence
Sequence (Aβ1-42):
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Product Specifications
| Parameter | Specification |
|---|---|
| Peptide Length | 42 amino acids |
| Molecular Weight | ~4514 Da |
| Purity | ≥95% (HPLC) |
| Form | Lyophilized powder |
| Solubility | DMSO / HFIP / dilute alkaline buffer |
| Storage | -20°C (desiccated) |
Quality Control
- ✔ HPLC analysis for purity confirmation
- ✔ Mass spectrometry (MS) verification
- ✔ Amino acid composition validation
- ✔ Endotoxin testing available upon request
Handling & Aggregation Notes
Aβ1-42 is highly aggregation-prone. To ensure reproducibility in experiments:
- Prepare fresh aliquots to avoid repeated freeze-thaw cycles
- Use HFIP pretreatment for monomerization if required
- Dissolve in DMSO or alkaline buffer before dilution into aqueous solutions
- Avoid vigorous shaking to reduce premature fibril formation
Frequently Asked Questions
What is β-Amyloid (1-42)?
A 42-amino-acid peptide strongly associated with Alzheimer’s disease and amyloid plaque formation.
What is the difference between Aβ1-40 and Aβ1-42?
Aβ1-42 is more hydrophobic and aggregates more readily, making it more relevant for pathology studies.
Is this peptide suitable for in vivo use?
No. This product is strictly for research use only (RUO), not for diagnostic or therapeutic use.
How is quality ensured?
Each batch is tested using HPLC and mass spectrometry to ensure purity and correct molecular weight.
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